激肽的中枢活性研究。
Studies on the central activity of kinins.
作者信息
Moniuszko-Jakoniuk J, Wiśniewski K
出版信息
Pol J Pharmacol Pharm. 1976 Nov-Dec;28(6):655-9.
The influence of bradykinin and kallikrein on the levels of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) as well as the influence of bradykinin on the levels of normetanephrine, homovanillic (HVA) and 5-hydroxyindoleacetic (5-HIAA) acids were investigated in different parts of the brain (cerebellum, corpus striatum, cortex, hippocampus, hypothalamus, medulla oblongata and midbrain). Kinins decrease the levels of NA and DA and their metabolites, and increase the level of 5-HT and 5-HIAA, expecially in corpus striatum and hypothalamus. The results of these investigations correlate with previously reported behavioural effects of kinins.
研究了缓激肽和激肽释放酶对去甲肾上腺素（NA）、多巴胺（DA）和5-羟色胺（5-HT）水平的影响，以及缓激肽对去甲变肾上腺素、高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）水平的影响，研究部位为大脑的不同区域（小脑、纹状体、皮层、海马体、下丘脑、延髓和中脑）。激肽可降低NA和DA及其代谢产物的水平，并增加5-HT和5-HIAA的水平，尤其是在纹状体和下丘脑。这些研究结果与先前报道的激肽的行为效应相关。
Zotero 插件