Valle L B, Oliveira-Filho R M, Armonia P L, Saraceni G, Nassif M, De Lucia R
Rev Bras Pesqui Med Biol. 1976 Dec;9(5-6):229-37.
In rats anestetized with urethane and under ganglionic blockade by hexamethonium (20 mg/kg, i.v.), the i.v. injection of serotonin (60 mug/kg) determined apnea, ECG alterations and a brief hypotensive response which is similar to that as elicited when 5-HT is given to intact rats. During the hypertension which follows that initial response, apnea is still present along with more severe ECG changes. After that, blood pressure falls into a prolonged hypotension, which is invariably accompanied by death. Neither norepinephrine, nor respiratory analeptics (CoramineR, RemeflinF) were able to prevent the fatal outcome. Only artificial respiration was found to be useful in some instances. It was concluded that the association serotonin plus lidocaine becomes lethal when given to ganglion-blocked rate, and this toxic effect can be ascribed mainly to the respiratory depressor activity of the drugs.
在用乌拉坦麻醉且处于六甲铵（20毫克/千克，静脉注射）神经节阻断状态的大鼠中，静脉注射血清素（60微克/千克）会导致呼吸暂停、心电图改变以及短暂的低血压反应，这与给完整大鼠注射5-羟色胺时引发的反应相似。在初始反应后的高血压阶段，呼吸暂停仍然存在，同时伴有更严重的心电图变化。之后，血压陷入长时间的低血压状态，并且总是伴随着死亡。去甲肾上腺素和呼吸兴奋剂（可拉明、回苏灵）均无法预防致命结局。仅发现人工呼吸在某些情况下有用。得出的结论是，血清素加利多卡因给予神经节阻断的大鼠时会致死，这种毒性作用主要可归因于药物的呼吸抑制活性。
