Demsey J W
Ottawa General Hospital, Ontario.
Can J Hosp Pharm. 1994 Oct;47(5):197-202.
A pilot study was designed to assess the feasibility of a shared regional drug use evaluation (DUE) program involving patients. A retrospective DUE on the use of benzodiazepines, chloral hydrate and neuroleptics for bedtime sedation was performed on geriatric patient populations from two hospitals. Regional program staff coordinated the DUE, including development of the criteria and chart review. The participating Pharmacy departments performed the internal administrative and Pharmacy and Therapeutics committee communications. Forty patient charts from two sites were reviewed. The DUE results indicated different rates of drug use and discontinuation of therapy between the two geriatric patient populations. The overall rates of inappropriate drug use were similar. One undesirable clinical outcome occurred. Benzodiazepine use for more than 30 days was high in both groups. Identification of the justification for drug use, dosage reduction and drug discontinuation did not occur in the majority of patients. The pilot study identified areas where use of bedtime sedation could be improved, and allowed development of DUE criteria for future evaluation.
一项试点研究旨在评估一项涉及患者的共享区域药物使用评估（DUE）计划的可行性。对两家医院老年患者群体使用苯二氮䓬类药物、水合氯醛和抗精神病药物进行睡前镇静的情况进行了回顾性药物使用评估。区域项目工作人员协调药物使用评估，包括制定标准和病历审查。参与的药学部门负责内部行政以及与药学和治疗学委员会的沟通。对来自两个地点的40份患者病历进行了审查。药物使用评估结果表明，两个老年患者群体之间的药物使用率和治疗中断率有所不同。不适当药物使用的总体发生率相似。发生了一例不良临床结局。两组中苯二氮䓬类药物使用超过30天的情况都很普遍。大多数患者未明确药物使用的理由、未进行剂量减少和停药。该试点研究确定了可以改进睡前镇静使用的领域，并为未来评估制定了药物使用评估标准。
