Frighetto L, Nickoloff D, Jewesson P
Vancouver Hospital and Health Sciences Centre, B.C.
Hosp Formul. 1995 Feb;30(2):92-3, 97-8, 100 passim.
To assess the long-term impact of a therapeutic interchange program on the use of target antimicrobial drugs, we conducted a retrospective study of target drug utilization at our institution--a 1,000-bed Canadian tertiary care teaching hospital. Data were assessed to determine target drug utilization, incidence of therapeutic interchanges, and patient-target drug exposures. Results showed that the incidence of therapeutic interchanges per patient-target drug exposure decreased from a mean of 23% to 2%, resulting in a total net savings for the target drugs of approximately $1.07 million (Canadian) over 6 years. Prescriber acceptance and low manpower requirements combine to make this a useful method of altering prescribing patterns and reducing drug and drug delivery costs.
为评估治疗性药物替换计划对目标抗菌药物使用的长期影响，我们对我院（一家拥有1000张床位的加拿大三级护理教学医院）的目标药物使用情况进行了一项回顾性研究。评估数据以确定目标药物使用情况、治疗性药物替换的发生率以及患者与目标药物的接触情况。结果显示，每位患者与目标药物接触时的治疗性药物替换发生率从平均23%降至2%，在6年时间里，目标药物总共节省了约107万加元。处方医生的接受度以及较低的人力需求共同使得这成为一种改变处方模式、降低药物及药物递送成本的有效方法。
