Properties of microsomal enzyme systems that reduce N-hydroxyphentermine.
作者信息
Sum C Y, Cho A K
出版信息
Drug Metab Dispos. 1976 Sep-Oct;4(5):436-41.
PMID:10142
Abstract
The reduction of N-hydroxyphentermine was studied in liver microsomes isolated from rat, guinea pig, and rabbit. The reduction requires a NADPH-generating system and was inhibited by oxygen and carbon monoxide. In the rat, the reduction was increased by phenobarbital pretreatment. Kinetic analysis of the reductase activity in rat liver microsomes suggests that the reduction of the hydroxylamine is mediated by at least two enzyme systems, one of which is a CO-sensitive system inducible by phenobarbital.
摘要
相似文献
1
Properties of microsomal enzyme systems that reduce N-hydroxyphentermine.
Drug Metab Dispos. 1976 Sep-Oct;4(5):436-41.
2
N-oxidation of phentermine to N-hydroxyphentermine by a reconstituted cytochrome P-450 oxidase system from rabbit liver.
Mol Pharmacol. 1982 Sep;22(2):235-8.
3
The metabolism of N-hydroxyphentermine by rat liver microsomes.
Drug Metab Dispos. 1979 Mar-Apr;7(2):65-9.
4
The oxidation of N-hydroxyphentermine by various oxidase systems.
Proc West Pharmacol Soc. 1979;22:105-7.
5
The microsomal N-oxidation of phentermine.
J Pharm Pharmacol. 1976 Sep;28(9):692-9. doi: 10.1111/j.2042-7158.1976.tb02838.x.
6
The N-hydroxylation of phentermine by rat liver microsomes.
Drug Metab Dispos. 1977 Sep-Oct;5(5):464-8.
7
Mechanism of azoreduction of dimethylaminoazobenzene by rat liver NADPH-cytochrome P-450 reductase and partially purified cytochrome P-450. Oxygen and carbon monoxide sensitivity and stimulation by FAD and FMN.大鼠肝脏NADPH-细胞色素P-450还原酶和部分纯化的细胞色素P-450对二甲基氨基偶氮苯的偶氮还原机制。对氧气和一氧化碳的敏感性以及FAD和FMN的刺激作用。
Drug Metab Dispos. 1988 May-Jun;16(3):441-8.
8
Bioreduction of organic nitrogen.有机氮的生物还原
Xenobiotica. 1971 Jul-Oct;1(4):469-81. doi: 10.3109/00498257109041512.
9
Role of superoxide in the N-oxidation of N-(2-methyl-1-phenyl-2-propyl)hydroxylamine by the rat liver cytochrome P-450 system.
Biochemistry. 1985 Jul 16;24(15):4155-61. doi: 10.1021/bi00336a051.
Zotero 插件