Dölp R, Ahnefeld F W, Schmitz E
Infusionsther Klin Ernahr. 1978 Oct;5(5):241-5.
We studied the changes in the concentration pattern of free plasma amino acids in 30 surgical patients during standardized parenteral nutrition and exclusive water and electrolyte supply. Distinct reproducible differences were found in comparison to normal subjects. The concentration of branched-chain amino acids continuously increases during the post-operative period. The decrease of alanine is closely related. Phenylalanine also increases continuously due to insufficient transformation in the liver and increased release from the muscles. During post-aggression metabolism, cystine is probably not sufficiently formed from methionine and should be substituted. It may be that tyrosine is also essential for patients in the post-operative post-traumatic period. The glycine concentration of some amino acid mixtures is regarded as too high; the glycine content can be reduced in favour of serine supply.
我们研究了30例外科手术患者在标准肠外营养及单纯水电解质供应期间血浆游离氨基酸浓度模式的变化。与正常受试者相比，发现了明显可重复的差异。术后支链氨基酸浓度持续升高。丙氨酸的降低与之密切相关。由于肝脏转化不足及肌肉释放增加，苯丙氨酸也持续升高。在应激后代谢过程中，蛋氨酸可能无法充分形成胱氨酸，应予以补充。术后创伤期患者可能也需要酪氨酸。某些氨基酸混合物中的甘氨酸浓度被认为过高；可以降低甘氨酸含量以利于丝氨酸的供应。
