Nicolau D P, Belliveau P P, Nightingale C H, Quintiliani R, Freeman C D
Hartford Hospital, CT 06102, USA.
Hosp Pharm. 1995 Aug;30(8):674-6, 679-80.
Recently, there has been an emergence of interest in the use of once-daily aminoglycoside dosing. In an attempt to take advantage of the pharmacodynamic properties of these agents and to reduce the potential for toxicity, a once-daily aminoglycoside program was developed at this institution. This program uses a fixed intravenous dose of 7 mg/kg with dosing interval adjustments based on estimates of creatinine clearance or a single random serum aminoglycoside concentration. Because this automatic conversion program was initiated hospital-wide, more than 2,400 patients received the regimen with no apparent alteration in clinical success and the incidence of toxicity was lower than that previously observed. The purpose of this report was to describe the implementation process and unique features of this hospital-wide once-daily aminoglycoside program in a 850-bed community-teaching hospital.
最近，人们对每日一次氨基糖苷类药物给药的应用产生了兴趣。为了利用这些药物的药效学特性并降低潜在毒性，本机构制定了每日一次氨基糖苷类药物给药方案。该方案采用7mg/kg的固定静脉给药剂量，并根据肌酐清除率估计值或单次随机血清氨基糖苷类药物浓度调整给药间隔。由于这个自动转换方案在全院范围内启动，超过2400名患者接受了该方案治疗，临床成功率没有明显变化，且毒性发生率低于之前观察到的情况。本报告的目的是描述在一家拥有850张床位的社区教学医院中全院范围内每日一次氨基糖苷类药物方案的实施过程和独特之处。
