Kotova D G, Razgovorova Z K
Vopr Onkol. 1976;22(10):51-7.
The use of lophenal in complex treatment of 27 patients with malignant ovarian tumors has shown that the substance possesses a definite antitumor activity, manifested in gaining the clinical effect in 60.9% of patients with an average duration of remission lasting for 5.3 months. The toxic effect on hemopoiesis as well as the side effect of the substance were liquidated by pharmacological drugs. It is concluded that lophenal should be used along with other chemotherapeutic drugs for treatment of patients with malignant ovarian tumors.
在对27例卵巢恶性肿瘤患者的综合治疗中使用洛非那尔,结果表明该物质具有一定的抗肿瘤活性,表现为60.9%的患者获得临床疗效,平均缓解期持续5.3个月。其对造血功能的毒性作用以及该物质的副作用可用药物消除。得出的结论是,洛非那尔应与其他化疗药物联合用于治疗卵巢恶性肿瘤患者。