Hoover M D, Harkema J R, Muggenburg B A, Spoo J W, Gerde P, Staller H J, Hotchkiss J A
Inhalation Toxicology Research Institute, Albuquerque, NM 87185.
J Aerosol Med. 1993 Summer;6(2):67-72. doi: 10.1089/jam.1993.6.67.
A microspray nozzle has been developed for the localized administration of solutions or suspensions to discrete pulmonary airway regions via bronchoscopy. Toxicants or tracer particles can be administered to single or multiple, specific lung airway segments. This permits studies of local-airway, whole-lung, and systemic responses to inhaled materials. The nozzle is fabricated by ultra-precision machining, has an overall length of 1 mm, and a diameter small enough to fit in the end of a 1.1-mm inner diameter, 1.2-mm outer diameter catheter. In vitro studies demonstrated the delivery efficiency for 99mTc solutions (98 +/- 1% SD) and for suspensions of 99mTc sulfur colloid or 3-mum 85Sr-labeled microspheres (55 +/- 15%). Photographic and gamma camera images of material deposited in the airways of Beagle dogs demonstrated in vivo that the deposition patterns are compact and uniform. The technique may also have therapeutic medical applications.
