Dzik S
Department of Pathology, Deaconess Hospital, Harvard Medical School, Boston, Mass.
Transfus Sci. 1994 Jun;15(2):131-9. doi: 10.1016/0955-3886(94)90087-6.
With the increasing demand for leukoreduced cellular blood components, many blood centers in Europe, North America, and Asia have begun to prepare leukocyte depleted cellular blood components prior to storage. Increased understanding of transfusion complications resulting from recipient exposure to residual donor leukocytes has focused attention on donor leukocytes during blood storage. This review examines production options for prestorage leukocyte removal, considers approaches to quality control, discusses proposed laboratory and clinical advantages of leukoreduction prior to storage compared with after storage, and suggests a strategy for cost-effective implementation of widespread prestorage leukocyte removal.
随着对白细胞滤除的细胞血液成分需求的增加，欧洲、北美和亚洲的许多血液中心已开始在储存前制备白细胞去除的细胞血液成分。对受血者接触残余供体白细胞所导致的输血并发症的进一步了解，使人们在血液储存期间将注意力集中在供体白细胞上。本文综述了储存前白细胞去除的生产选择，考虑了质量控制方法，讨论了与储存后白细胞去除相比，储存前白细胞去除在实验室和临床方面的潜在优势，并提出了一种具有成本效益的广泛实施储存前白细胞去除的策略。
