Schiffer R B, Giang D W, Mushlin A, Ketonen L, Joy S, Kido D, Goodman A D, Mattson D H, Mooney C
J Neuroimaging. 1993 Apr;3(2):81-8. doi: 10.1111/jon19933281.
Purpose. Magnetic resonance imaging (MRI) has come to assume a position of major importance in the diagnostic process for multiple sclerosis (MS). The authors believe that a tendency toward overreliance on MRI results in isolation from clinical findings continues to result in both false-positive and false-negative diagnostic errors. Methods. To evaluate this, MRI results in newly referred patients with clinical findings suggestive, but not diagnostic, for MS, were studied prospectively. Results. Of 99 consecutive referrals for suspected MS, there were 3 false-positive diagnoses of MS and 7 false-negatives, when the MRIs were read in isolation from specific clinical data. None of the scans in the false-negative groups were normal. Representative images of both groups are provided. Conclusion. In newly referred patients who fall short of criteria for definite MS, it remains dangerous for both clinicians and radiologists to rely too heavily only on MRI results.
目的。磁共振成像（MRI）在多发性硬化症（MS）的诊断过程中已占据重要地位。作者认为，过度依赖MRI结果而脱离临床发现的倾向继续导致假阳性和假阴性诊断错误。方法。为评估这一点，对新转诊的有提示MS但不能确诊的临床表现的患者的MRI结果进行前瞻性研究。结果。在连续99例疑似MS的转诊病例中，当MRI结果脱离特定临床数据单独解读时，有3例假阳性MS诊断和7例假阴性诊断。假阴性组的扫描结果均不正常。提供了两组的代表性图像。结论。在未达到明确MS标准的新转诊患者中，临床医生和放射科医生过度依赖MRI结果仍然是危险的。
