Andriulli A, Gremo L, Limerutti G, Bianchi A, Berti E, Arrigoni A, Napolitano G, Cirillo R
Division of Gastroenterology, Ospedale Regionale "Casa Sollievo della Sofferenza," I.R.C.C.S., San Giovanni Rotondo, Italy.
J Stone Dis. 1993 Apr;5(2):96-104.
The success of extracorporeal shock wave lithotripsy (ESWL) for gallstone elimination is dependent on the lithotripter's ability to reduce the stone to fragments less than 5 mm in diameter, but wide variation in successful fragmentation rates have been reported even with the same instrument. This variation is probably due in part to differences in stone composition. Tsuchiya et al. have recently related the pre-operative ultrasound properties of gallstones to their chemical compositions. In the present study, 138 patients with cholecystolithiasis were treated with ESWL and results were evaluated in light of the pre-treatment sonogram patterns as classified by the aforementioned authors. Complete fragmentation (CF), i.e., fragments less than 5 mm, was achieved in 90% of patients with type I a patterns (pure cholesterol stones); stone number, diameter, and volume had no effects on fragmentation. Significantly lower CF rates were obtained with I b and I c (mixed cholesterol), and type II (combination) stones (p less than 0.0003). No fragmentation at all was achieved in the six stones with type III (bilirubinate) patterns. Twelve months after treatment, 45%, 25%, and 9% of the patients with type 1 a, type I b, and types I c or II (the latter two combined), respectively, were stone-free. Pure and mixed cholesterol gallstones without calcification seem to respond best to ESWL; effective treatment can be expected even when stones are numerous (4-10) or large ( greater than 35 mm). We recommend the inclusion of ultrasound properties of gallstones in the selection criteria for candidates for ESWL.
体外冲击波碎石术(ESWL)消除胆结石的成功与否取决于碎石器将结石粉碎成直径小于5毫米碎片的能力,但即便使用同一台仪器,其成功碎石率也存在很大差异。这种差异可能部分归因于结石成分的不同。土屋等人最近将胆结石的术前超声特性与其化学成分联系起来。在本研究中,138例胆囊结石患者接受了ESWL治疗,并根据上述作者分类的治疗前超声图像模式对结果进行了评估。I a型(纯胆固醇结石)患者中有90%实现了完全粉碎(CF),即碎片小于5毫米;结石数量、直径和体积对粉碎效果没有影响。I b型和I c型(混合胆固醇)以及II型(复合型)结石的CF率明显较低(p小于0.0003)。III型(胆红素盐)模式的6颗结石完全没有实现粉碎。治疗12个月后,I a型、I b型以及I c型或II型(后两者合并)患者的结石清除率分别为45%、25%和9%。无钙化的纯胆固醇结石和混合胆固醇结石似乎对ESWL反应最佳;即使结石数量众多(4 - 10颗)或体积较大(大于35毫米),也有望获得有效治疗。我们建议在ESWL候选者的选择标准中纳入胆结石的超声特性。