Jabr A K, Straus S, Brewster R, Rodriguez R, Panos A, Hieb B, Perry J, Daugharthy J
Cardio-Pulmonary Resources, Las Vegas, NV 89104.
J Extra Corpor Technol. 1990 Fall;22(3):107-9.
Hypothermia is used to prolong the safe period of ischemic arrest by reducing the heart's oxygen demands. Due to this effect, hypothermia has been the fundamental component of most methods of myocardial protection during cardiac surgery. However, hypothermia has a number of unwanted side effects, such as detrimental effects on enzyme function, energy generation, and cell membranes. Since electromechanical arrest accounts for 90% of myocardial oxygen consumption, arresting the heart with chemical cardioplegia will reduce O2 consumption dramatically. Therefore, if the resting (arrested) heart is continuously perfused with oxygenated blood cardioplegia, one can easily provide the remaining 10% of O2 that it requires. Under these conditions, the need for hypothermia becomes questionable. In this paper, we describe the perfusionist's experience using the antegrade and retrograde technique of continuous warm blood cardioplegia.
低温可通过降低心脏的氧需求来延长缺血性停搏的安全时间。由于这一作用，低温一直是心脏手术中大多数心肌保护方法的基本组成部分。然而，低温有许多不良副作用，如对酶功能、能量生成和细胞膜产生有害影响。由于机电活动停止占心肌氧消耗的90%，用化学心脏停搏液使心脏停搏将显著降低氧消耗。因此，如果用含氧血液心脏停搏液持续灌注静止（停搏）的心脏，就可以轻松提供其所需其余10%的氧气。在这些情况下，对低温的需求就值得怀疑了。在本文中，我们描述了灌注师使用顺行和逆行持续温血心脏停搏技术的经验。
