Factors influencing the performance of temporary skin substitutes.

Advances in our knowledge of the wound healing process has led to the development of various synthetic skin substitutes, which when applied to the wound surface provide a microclimate conducive to healing. The requirements of an ideal temporary skin substitute are presented. This review also provides an updated account of the preclinical evaluation procedures utilized to assess these demands, particularly important parameters such as water vapour permeability, adherence to excised wound surface, oxygen permeability, mechanical properties, microbial permeability and exudate soaking capacity.