Rolle D J, Kretschmar K H
Zentralbl Allg Pathol. 1976;120(5):383-90.
Investigations were made on the angio-architecture of intramuscularily implanted Yoshida-sarcomas in untreated Wistar-rats and in animals treated with lithium carmine. The injected quantity of lithium carmine led to RES-activation according to the data in the literature. The presentation of the vessels was made by corrosion technique using the synthetic material KALLOCRYL after rinsing the vessels with the proper ester. The pre-existent vessels in the surrounding of the tumor showed an adaptation the expansive growth of the tumor. After starting the experiment the tumor-owned vessels showed an increasing tendency to grow out. The vessels of the treated animals rected in a more regularly and orientated course than those of the untreated animals. In the following time vascularisation in the untreated animals was considerably decreasing, whereas a clear vascularisation was evident in the treated animals until the end of the study. These different findings may be the expression of a local vascular reaction in the implanted tumor following RES-activation induced by lithium carmine.
对未治疗的Wistar大鼠和用锂卡红治疗的动物体内肌肉植入吉田肉瘤的血管结构进行了研究。根据文献数据，注入的锂卡红量导致了网状内皮系统（RES）激活。在用适当的酯冲洗血管后，使用合成材料KALLOCRYL通过腐蚀技术呈现血管。肿瘤周围预先存在的血管显示出对肿瘤扩张性生长的适应性。开始实验后，肿瘤自身的血管显示出向外生长的增加趋势。与未治疗动物的血管相比，治疗动物的血管走向更规则且更具方向性。在接下来的时间里，未治疗动物的血管化程度大幅下降，而在治疗动物中直到研究结束都有明显的血管化现象。这些不同的发现可能是锂卡红诱导RES激活后植入肿瘤中局部血管反应的表现。
