Hecht K, Ljowschina I P, Schlegel T, Poppei M, Treptow K
Acta Biol Med Ger. 1976;35(7):973-82.
Male adult albino rats living from the 6th week of their lives under conditions of artificial light-dark cycle (16 hrs light, 8 hrs dark) were used to study possible relationships between circadian sensitivity cycles and synchronization of dynamics and the frequency variability of periodicities of reaction times of conditional-reflectory processes with wavelengths in the minute range. The experiments have revealed differences at the time of the activity maximum and minimum of a circadian cycle in the studied parameters of the minute rhythm (mean level of oscillation, mean amplitude, length of period and coupling). In the dark phase (activity maximum) there prevailed an increased level of central-nervous excitation and a tendency towards a higher frequency and diminished coupling of minute periods. In the light phase (activity minumum) the animals showed a balanced level of excitation, reduced frequency and a rigid coupling of periodicities of conditional-reflectory events involved in the process. Relations are shown to exist between central-nervous processes and circadian sensitivity cycles. For the experimental practice it is concluded that the different times of the day should be accounted for in assessing the criteria of minute rhythm and in conditional-reflectory studies in pharmacology and toxicology.
选用从出生第6周起生活在人工光暗周期（16小时光照，8小时黑暗）条件下的成年雄性白化大鼠，来研究昼夜敏感性周期与动态同步性之间的可能关系，以及条件反射过程反应时间的周期性在分钟范围内的频率变化与波长之间的关系。实验揭示了在昼夜节律周期的活动最大值和最小值时，分钟节律的研究参数（平均振荡水平、平均振幅、周期长度和耦合）存在差异。在黑暗阶段（活动最大值），中枢神经兴奋水平升高，且存在分钟周期频率更高和耦合减弱的趋势。在光照阶段（活动最小值），动物表现出平衡的兴奋水平、频率降低以及该过程中条件反射事件的周期性紧密耦合。结果表明中枢神经过程与昼夜敏感性周期之间存在关联。对于实验实践而言，得出的结论是，在评估分钟节律标准以及药理学和毒理学中的条件反射研究时，应考虑一天中的不同时间。
