Bo J, Sudmann E, Marton P F
Acta Orthop Scand. 1976 Dec;47(6):588-99. doi: 10.3109/17453677608988744.
The healing of closed, non-immobilized femoral fractures in rats was seriously impaired by indomethacin given orally at a dose of 2 mg/kg daily. The fracture haematomas were larger and disappeared later in the animals receiving indomethacin. Mechanical strength testing of fracture healing showed that maximal tensile strength, elastic stiffness and maximal bending moment between fragments were significantly diminished in the indomethacin-treated animals. Radiological examination showed a smaller amount of mineralized callus and a more pronounced angulation between the fragments in these animals than in the placebo-treated ones. Hsitological examination showed bridging between the fragments by callus tissue 24 days after fracture in placebo-treated animals, whereas indomethacin treatment was followed by histological findings resembling those seen in early pseudarthrosis development.
大鼠闭合性、非固定性股骨骨折的愈合因每日口服2 mg/kg剂量的吲哚美辛而受到严重损害。接受吲哚美辛治疗的动物骨折血肿更大且消退更晚。骨折愈合的力学强度测试表明，接受吲哚美辛治疗的动物其最大拉伸强度、弹性刚度以及骨折碎片间的最大弯矩均显著降低。放射学检查显示，与接受安慰剂治疗的动物相比，接受吲哚美辛治疗的动物矿化骨痂量更少，骨折碎片间成角更明显。组织学检查显示，接受安慰剂治疗的动物在骨折后24天可见骨痂组织在骨折碎片间形成桥接，而吲哚美辛治疗后的组织学表现类似于早期假关节形成时所见。
