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二价离子参与乙酰胆碱引发的胃平滑肌阶段性收缩。

Participation of bivalent ions in the acetylcholine-provoked gastric smooth-muscle phasis contractions.

作者信息

Boev K, Papasova M

出版信息

Acta Physiol Pharmacol Bulg. 1976;2(3):6-14.

PMID:1015320
Abstract

Experiments were carried out on muscle strips from cat antrum. Acetylcholine added to Ca++ -free medium containing EDTA (10-5M) exerted no effect on the phasic contractions of the gastric smooth muscle. Ba++at low concentrations (0,1 to 0,5mM) replaced Ca++with respect to the acetylcholine effect. On the background of blocked cholinergic (atropine 10-5M) and adrenergic (phentolamine 10-5 M and propranolol 10-5M) structures Ba++ provoked slow potentials and cotractions with a frequency of 9 to 10 cpm. delta600 (10-5M) blocked the Ba++-induced myogenic electrical and contractile activities of the smooth muscle. The role of the cholinergic structures for synchronizing the electrical and contractile activities of the smooth muscle is considered.

摘要

在猫胃窦的肌肉条上进行了实验。将乙酰胆碱添加到含有乙二胺四乙酸(10⁻⁵M)的无钙培养基中,对胃平滑肌的相性收缩没有影响。低浓度(0.1至0.5mM)的钡离子在乙酰胆碱作用方面替代了钙离子。在胆碱能(阿托品10⁻⁵M)和肾上腺素能(酚妥拉明10⁻⁵M和普萘洛尔10⁻⁵M)结构被阻断的背景下,钡离子引发了频率为9至10次/分钟的慢电位和收缩。δ600(10⁻⁵M)阻断了钡离子诱导的平滑肌肌源性电活动和收缩活动。文中考虑了胆碱能结构在使平滑肌电活动和收缩活动同步方面的作用。

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