Ivey K J
Am J Dig Dis. 1976 Dec;21(12):1033-6. doi: 10.1007/BF01071859.
The effect of carbenoxolone on the output of salivary electrolytes stimulated by a nasogastric tube was studied in healthy volunteers. Mean +/- SE values for volume and electrolyte concentrations in control studies were volume 121 +/- 19 ml/hr, pH7.39, Na+19 +/-5, K+20 +/- U, Cl-20 +/- 3, HCO3-18 MEq/liter and osmolality 71 +/- 8 mOsm/kg. Mean +/- electrolyte outputs were quite large, Na+ 2.4, k+2.4, Cl-26, and bicarbonate 2.2 mEq/hr. Our control data indicate that in the course of gastric secretory testing the indwelling gastric tube stimulates salivary electrolyte output sufficient to interfere with accurate assessment of gastric ionic fluxes and gastric acid analysis. Therapeutic doses of carbenoxolone (100 mg three times daily) given orally for 3 weeks had no effect on salivary volume, electrolyte output, or concentration. We conclude that carbenoxolone has no minerallocorticoid effect on mixed salivary secretion. Attention to salivary secretion is recommended in all gastric secretory studies and is mandatory where low acid output is suspected.
在健康志愿者中研究了甘珀酸对经鼻胃管刺激后的唾液电解质分泌量的影响。对照研究中，唾液量和电解质浓度的均值±标准误分别为：唾液量121±19毫升/小时，pH值7.39，钠离子19±5，钾离子20±1，氯离子20±3，碳酸氢根离子18毫当量/升，渗透压71±8毫摩尔/千克。平均±电解质分泌量相当大，钠离子2.4、钾离子2.4、氯离子26以及碳酸氢根离子2.2毫当量/小时。我们的对照数据表明，在胃分泌试验过程中，留置胃管会刺激唾液电解质分泌，足以干扰对胃离子通量和胃酸分析的准确评估。口服治疗剂量的甘珀酸（每日3次，每次100毫克），持续3周，对唾液量、电解质分泌量或浓度均无影响。我们得出结论，甘珀酸对混合唾液分泌没有盐皮质激素样作用。建议在所有胃分泌研究中关注唾液分泌，而在怀疑胃酸分泌量低的情况下则必须关注。
