Boland J, Lisin N, Marcelle R, Carlier J
Arch Int Pharmacodyn Ther. 1976 Nov;224(1):145-51.
A single dosis of disopyramide (100 mg), given intravenously in 10 min to 30 patients admitted in the coronary or respiratory care unit, induces a reduction of cardiac output of 13.4%, which is highly statistically significant, without altering the systemic and pulmonary pressures. The heart rate is also slightly diminished.