Serafin B, Majewski M, Kleinrok Z, Jagiełło-Wojtowicz E, Rajtar G, Sieklucka-Dziuba M, Kolasa K
Arch Immunol Ther Exp (Warsz). 1976;24(6):901-10.
Out of 12 oximes and amidoximes (3 of which were new to the literature) the following showed a distinct antilethal effect in DFP poisoning: RA14 (1-methylbenzimidazole-2-aldoxime methiodide), RA14 (pyridine-4-aldoxime dodecyl bromide), and RA24 (pyridine-2-aldoxime dodecyl bromide). These compounds also reactivated acetylcholinesterase (AChE) in vitro, but had no effect on this enzyme in vivo. Moreover, addition of the dodecyl chain to pyridinealdoxtimes, or in a less degree replacement of the pyridine ring with benzimidazole in aldoximes, distinctly increased acute toxicity and lipophilicity when compared with the parent pyridine compounds, along with protective action in DFP poisoning.
在12种肟和偕胺肟（其中3种为文献中首次报道）中，以下几种在二异丙基氟磷酸酯（DFP）中毒时表现出明显的抗致死作用：RA14（1-甲基苯并咪唑-2-醛肟甲碘化物）、RA14（吡啶-4-醛肟十二烷基溴化物）和RA24（吡啶-2-醛肟十二烷基溴化物）。这些化合物在体外也能使乙酰胆碱酯酶（AChE）重新活化，但在体内对该酶无作用。此外，与母体吡啶化合物相比，在吡啶醛肟中添加十二烷基链，或在醛肟中用苯并咪唑较少程度地取代吡啶环，明显增加了急性毒性和亲脂性，同时在DFP中毒时有保护作用。
