Newman S P
Pharmaceutical Profiles Ltd., Highfields Science Park, Nottingham, UK.
J Aerosol Med. 1996 Mar;9 Suppl 1:S37-47. doi: 10.1089/jam.1996.9.suppl_1.s-37.
The total and regional deposition patterns of aerosols released from pressurized metered dose inhalers (MDIs) may be determined by gamma scintigraphy. Owing to difficulties in chemically labelling drug molecules themselves, the formulation may be radiolabelled with a suitable gamma-ray-emitting radionuclide (usually 99mTc). Validation measurements must then be performed to check that the drug formulation has not been altered significantly by the radiolabelling process and that the radiolabel acts as an adequate marker for the drug across the full range of particle sizes. These radiolabelling techniques have proved widely applicable, not only to pressurized MDIs, but also to dry powder formulations.
通过γ闪烁扫描法可以确定压力定量吸入器（MDIs）释放的气溶胶的总体和局部沉积模式。由于对药物分子本身进行化学标记存在困难，制剂可用合适的发射γ射线的放射性核素（通常为99mTc）进行放射性标记。然后必须进行验证测量，以检查药物制剂在放射性标记过程中是否未发生显著改变，以及放射性标记在整个粒径范围内是否能作为药物的充分标记物。这些放射性标记技术已被证明具有广泛的适用性，不仅适用于压力定量吸入器，也适用于干粉制剂。
