Farr S J
Welsh School of Pharmacy, University of Wales, Cardiff, UK.
J Aerosol Med. 1996 Mar;9 Suppl 1:S27-36. doi: 10.1089/jam.1996.9.suppl_1.s-27.
Over the past decade, a number of different approaches have been proposed for the radiolabelling of metered dose inhalers (MDIs) in order to permit gamma scintigraphic imaging of emitted aerosols following inhaled administration. More recently, methods have been described for the indirect 99mTc-labelling of drugs incorporated into commercial MDI products. This paper attempts to rationalise such methods from a surface chemical perspective in order to: I) elucidate the mechanism of association of the radiolabel and drug; 2) predict the appropriateness of the techniques to all MDI products and; 3) propose in vitro testing methods to validate the labelling efficiency prior to in vivo evaluation.
在过去十年中，已经提出了许多不同的方法用于定量吸入器（MDIs）的放射性标记，以便在吸入给药后对呼出的气溶胶进行γ闪烁成像。最近，已经描述了将商业MDI产品中所含药物间接进行99mTc标记的方法。本文试图从表面化学的角度对这些方法进行合理化分析，以便：1）阐明放射性标记物与药物的结合机制；2）预测这些技术对所有MDI产品的适用性；3）提出体外测试方法，以在体内评估之前验证标记效率。
