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The influence of calcium and beta-sympathomimetics on force-frequency relationship and resting potentiation in guinea pig papillary muscle.

作者信息

Hanafy M, Kitzing J, Rumberger E

出版信息

Basic Res Cardiol. 1976 Sep-Oct;71(5):469-81. doi: 10.1007/BF01909763.

DOI:10.1007/BF01909763
PMID:1016186
Abstract

The influence of various calcium concentrations and of the beta-sympathomimeticum orciprenaline (Alupent) on the force-frequency relationship and on the resting potentiation of isolated isometrically contracting papillary muscles of the guinea pig heart was studied. Elevation of Ca concentration and/or addition of orciprenaline augment the amplitudes of contractions elicited by rhythmical stimulation, but they diminish the amplitudes of test contractions elicited after a test interval of 1-2 s. It is suggested that calcium and orciprenaline strengthen the calcium loss from the sarcoplasmic reticulum out of the cell during a prolonged interval.

摘要

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本文引用的文献

1
The action of ions and lipoids upon the frog's heart.离子和类脂对蛙心的作用。
J Physiol. 1913 Oct 17;47(1-2):66-107. doi: 10.1113/jphysiol.1913.sp001614.
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On the Rhythm of the Mammalian Heart.论哺乳动物心脏的节律
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[THE POSITIVE INOTROPIC EFFECT OF ADRENALIN ON THE GUINEA PIG PAPILLARY MUSCLE DURING VARIATION OF THE EXTERNAL CALCIUM AND SODIUM CONCENTRATION].[肾上腺素对豚鼠乳头肌在细胞外钙和钠浓度变化时的正性肌力作用]
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[OSCILLATORY CONTRACTION PHENOMENA OF THE MYOCARDIUM UNDER THE INFLUENCE OF ADRENALIN].[肾上腺素影响下心肌的振荡性收缩现象]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Feb 2;250:21-34.
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THE INFLUENCE OF THE INTERVAL BETWEEN BEATS ON MYOCARDIAL CONTRACTILITY.心动周期对心肌收缩力的影响。
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Uniformity of the contractile response of ventricular muscle in high-calcium Tyrode's solution.高钙台氏液中心室肌收缩反应的一致性。
Nature. 1962 Dec 15;196:1104-6. doi: 10.1038/1961104b0.
9
Movements of Ca in beating ventricles of the frog heart.蛙心搏动心室中钙的运动。
J Physiol. 1963 Jul;167(3):551-80. doi: 10.1113/jphysiol.1963.sp007167.
10
The importance of calcium in poststimulation potentiation.钙在刺激后增强中的重要性。
J Gen Physiol. 1961 Jul;44(6):1059-72. doi: 10.1085/jgp.44.6.1059.