Casti A, Morini G, Reali N, Fior T D, Rabbi A
Ateneo Parmense Acta Biomed. 1976 Jan-Feb;47(1):47-58.
Carbenoxolone was administrated, by intubation per os, to guinea-pigs, then the animals were killed 2 and 4 hours later. In perfusion experiments, carbenoxolone was injected for 5,10 and 20 min respectively. The results show a decreased uptake of formiate-H3 into RNA and DNA in vivo. During perfusion of stomach, CBO causes a precocious enhancement of specific radioactivity of nucleic acids, then a decrease was observed. The pattern of polyamines in perfused stomach shows an increased uptake of putrescine-C14 into spermidine. Finally, the specific radioactivity of proteins was enhanced in vivo and in vitro by CBO. The results demonstrate that the drug alterates the proliferative cell cycle and induces the synthesis of proteins.
将甘草次酸通过经口插管给予豚鼠，然后在2小时和4小时后处死动物。在灌注实验中，分别注射甘草次酸5、10和20分钟。结果显示，体内甲酸-H3进入RNA和DNA的摄取减少。在胃灌注期间，甘草次酸导致核酸比放射性早熟增强，随后观察到降低。灌注胃中多胺的模式显示，腐胺-C14进入亚精胺的摄取增加。最后，甘草次酸在体内和体外均增强了蛋白质的比放射性。结果表明，该药物改变了增殖细胞周期并诱导了蛋白质的合成。
