Fleming J S, Hashish A H, Conway J H, Nassim M A, Holgate S T, Halson P, Moore E, Bailey A G, Martonen T B
Department of Medical Physics, Southampton General Hospital, U.K.
J Aerosol Med. 1996;9(3):317-27. doi: 10.1089/jam.1996.9.317.
Multimodality medical imaging enables measurement of the three-dimensional spatial distribution of a radiolabeled aerosol within the lung. Using a conceptual spatial morphological model these data may be transformed to provide information on deposition per airway generation. This methodology has been used to study the intrapulmonary deposition patterns of two formulations of a metered dose inhaler and two nebulizers in control subjects. The nebulizer study has also been stimulated using a computer model of deposition. The comparison between derived experimental results and those from computer modeling shows areas of agreement, although there are also areas of discrepancy. The new methodology has considerable potential value in the fields of inhalation therapy and deposition modeling, although more detailed validation is still required.
多模态医学成像能够测量放射性标记气溶胶在肺内的三维空间分布。利用概念性空间形态模型，这些数据可以进行转换，以提供关于每个气道代沉积的信息。该方法已被用于研究对照受试者中定量吸入器的两种制剂和两种雾化器的肺内沉积模式。还使用沉积计算机模型对雾化器研究进行了模拟。虽然也存在差异，但推导的实验结果与计算机模拟结果之间的比较显示出一致的领域。尽管仍需要更详细的验证，但这种新方法在吸入治疗和沉积建模领域具有相当大的潜在价值。
