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[不同类型过度喂养对大鼠血管壁状态的影响]

[Effect of different types of excessive feeding on the state of vascular walls in rats].

作者信息

Nasledova I D, Fashchevskaia I A, Khmel'nitskaia T O, Shaposhnikova E S

出版信息

Biull Eksp Biol Med. 1976;82(11):1297-8.

PMID:1016702
Abstract

Immature male rats were overfed for a long time with an excess of fats or carbohydrates; this caused obesity. Carbohydrate overfeeding led to a greater body weight gain and a greater increase in the weight of epididymal fat and of the adipose cell volume than fat overfeeding, but failed to decrease the lipolytic activity of the aorta. Prolonged fat overfeeding decreased the lipolytic activity of the aorta considerably. Thus, the results of the mentioned experiments showed that the predisposition of the aortic wall to atherogenesis did not correlate with the gain in weight and depended on the character of nutrition.

摘要

未成熟雄性大鼠长期过量喂食脂肪或碳水化合物;这导致了肥胖。与过量喂食脂肪相比,过量喂食碳水化合物导致体重增加更多,附睾脂肪重量和脂肪细胞体积增加更大,但未能降低主动脉的脂解活性。长期过量喂食脂肪显著降低了主动脉的脂解活性。因此,上述实验结果表明,主动脉壁易发生动脉粥样硬化与体重增加无关,而是取决于营养特性。

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