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用于良性前列腺增生的前列腺支架

Prostatic stents for benign prostatic hyperplasia.

作者信息

Klein L T, Kaplan S A

机构信息

Department of Urology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.

出版信息

J Long Term Eff Med Implants. 1997;7(1):101-14.

Abstract

Treatment options for benign prostatic hyperplasia (BPH) have developed rapidly over the past several years. These options include surgical intervention, medical therapy, and minimally invasive modalities such as prostatic stents. Prostatectomy remains the treatment of choice for symptoms that are the result of bladder outflow obstruction, with success rates of 85-90%. Medical therapy with selective alpha-1 antagonists, 5 alpha-reductase inhibitors, LHRH antagonists, antiandrogens, and aromatase inhibitors have increased in popularity and are mainly used to treat patients with mild to moderate prostatic obstruction. Prostatic urethral stents have recently emerged as an alternative treatment for BPH throughout Europe and Asia, but few investigators have used prostatic stents in the United States because of strict regulatory forces and a debate concerning the indications for these devices. The possibility of providing a treatment option for BPH to patients who are frail and elderly, as well as to patients with multiple medical problems, has prompted enthusiasm toward prostatic stents in the urologic community. The focus of this review will be an up-to-date discussion of the types of prostatic stent available, including a review of recent clinical trials involving the use of each available stent.

摘要

在过去几年中,良性前列腺增生(BPH)的治疗选择发展迅速。这些选择包括手术干预、药物治疗以及诸如前列腺支架等微创方式。前列腺切除术仍然是因膀胱流出道梗阻导致症状的首选治疗方法,成功率为85%至90%。使用选择性α-1拮抗剂、5α-还原酶抑制剂、促性腺激素释放激素(LHRH)拮抗剂、抗雄激素药物和芳香化酶抑制剂的药物治疗越来越受欢迎,主要用于治疗轻度至中度前列腺梗阻的患者。前列腺尿道支架最近在欧洲和亚洲成为BPH的一种替代治疗方法,但由于严格的监管力量以及关于这些设备适应证的争论,在美国很少有研究者使用前列腺支架。为体弱和老年患者以及患有多种疾病的患者提供BPH治疗选择的可能性,激发了泌尿外科界对前列腺支架的热情。本综述的重点将是对现有前列腺支架类型的最新讨论,包括对涉及使用每种可用支架的近期临床试验的综述。

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