Ramos A, Meyer R A, Korfhagen J, Wong K Y, Kaplan S
Cancer Treat Rep. 1976 Sep;60(9):1281-4.
Thirty children with malignant solid tumors receiving adriamycin had serial evaluation of left ventricular (LV) function by echocardiography. The echocardiographic studies showed a progressive decrease in myocardial contractility as evidenced by changes in several parameters of LV function with increasing cumulative doses of the drug. Using the patients as their own controls, serial echocardiography appears to be a reliable method for detecting early alteration of cardiac function in the asymptomatic patient. This technique may prove useful to prevent cardiomyopathy secondary to adriamycin and to prolong therapy beyond the currently established limits.
30名接受阿霉素治疗的恶性实体瘤患儿通过超声心动图对左心室（LV）功能进行了系列评估。超声心动图研究显示，随着药物累积剂量的增加，左心室功能的几个参数发生变化，心肌收缩力逐渐下降。将患者自身作为对照，系列超声心动图似乎是检测无症状患者心脏功能早期改变的可靠方法。该技术可能有助于预防阿霉素所致的心肌病，并使治疗时间延长至目前确定的极限之外。
