Benghuzzi H A, Bajpai P K, England B G
Department of Biology, The University of Dayton, OH 45469.
J Appl Biomater. 1990 Fall;1(3):233-40. doi: 10.1002/jab.770010306.
The capability of ALCAP ceramic drug-delivery implantable devices to release testosterone for 12 months was investigated. A total of 120 Sprague-Dawley male albino rats were distributed equally into three groups. Two ALCAP capsules, one nonimpregnated and the other impregnated with polylactic acid (PLA) were implanted into each rat in Groups I and II. Capsules implanted into Group I rats were loaded with 40 mg testosterone (T) each. Group II rats were implanted with two empty capsules (sham group), and Group III animals served as unimplanted controls. Eight rats from each group were euthanized at the end of 1, 3, 6, 9, and 12 months following the implantation of the ceramics. No significant changes in the weights of vital organs of rats were observed between any of the three different groups. Vas deferens and epididymal fluid were devoid of normal spermatozoa within 3 months of implanting the steroid-containing ceramics. Testes and epididymis weights decreased significantly in the rats implanted with ALCAP ceramics containing steroid, and the seminiferous tubules became oligospermic after 1 month and azoospermic after 3 months. Circulating levels of both LH and FSH hormones were suppressed in experimental rats. Serum T level was lower than the control but showed no significant difference in comparison to control rats. The data collected in this study suggest that: (a) ALCAP ceramic capsules are capable of delivering T in a sustained manner for 12 months; (b) T delivered by ALCAP capsules can be used effectively to regulate spermatogenesis in rats.
研究了ALCAP陶瓷药物递送可植入装置释放睾酮12个月的能力。总共120只Sprague-Dawley雄性白化大鼠被平均分为三组。在第一组和第二组的每只大鼠中植入两个ALCAP胶囊，一个未浸渍，另一个浸渍有聚乳酸（PLA）。植入第一组大鼠的胶囊每个装载40mg睾酮（T）。第二组大鼠植入两个空胶囊（假手术组），第三组动物作为未植入的对照。在植入陶瓷后的1、3、6、9和12个月结束时，每组处死8只大鼠。在三个不同组中的任何一组之间，未观察到大鼠重要器官重量的显著变化。在植入含类固醇陶瓷的3个月内，输精管和附睾液中没有正常精子。植入含类固醇的ALCAP陶瓷的大鼠的睾丸和附睾重量显著下降，生精小管在1个月后变为少精子症，在3个月后变为无精子症。实验大鼠中促黄体生成素（LH）和促卵泡生成素（FSH）激素的循环水平均受到抑制。血清T水平低于对照组，但与对照大鼠相比无显著差异。本研究收集的数据表明：（a）ALCAP陶瓷胶囊能够持续递送T达12个月；（b）ALCAP胶囊递送的T可有效地用于调节大鼠的精子发生。
