Noguchi T, Yamamuro T, Oka M, Kumar P, Kotoura Y, Hyon S, Ikada Y
Department of Orthopaedic Surgery, Kyoto University, Japan.
J Appl Biomater. 1991 Summer;2(2):101-7. doi: 10.1002/jab.770020205.
We have developed a new poly(vinyl alcohol) hydrogel (PVA-H) of increased physical strength through a new manufacturing process. Its mechanical properties have been found to be preferable as a substitute for articular cartilage. To evaluate its biocompatibility as an artificial articular cartilage, a series of in vivo tests within the intraarticular, as well as the intramuscular, environment were conducted. Tissue reactions of cartilage, bone, synovium, and muscle to PVA-H were studied histologically. In the experimental group, in which PVA-H was implanted, inflammatory reactions of all of these tissues were very slight. In the control group, in which ultra-high molecular weight polyethylene (UHMWPE) was implanted, although tissue reactions of bone and muscle were as slight as in the experimental group, those of cartilage and synovium were somewhat more conspicuous. By way of these findings, the better biocompatibility of PVA-H was documented.
我们通过一种新的制造工艺开发出了一种物理强度更高的新型聚乙烯醇水凝胶（PVA-H）。已发现其机械性能作为关节软骨的替代品较为理想。为了评估其作为人工关节软骨的生物相容性，我们在关节内以及肌肉内环境中进行了一系列体内试验。通过组织学研究了软骨、骨、滑膜和肌肉对PVA-H的组织反应。在植入PVA-H的实验组中，所有这些组织的炎症反应都非常轻微。在植入超高分子量聚乙烯（UHMWPE）的对照组中，尽管骨和肌肉的组织反应与实验组一样轻微，但软骨和滑膜的反应则更为明显。通过这些发现，证明了PVA-H具有更好的生物相容性。
