Espy P D, Stone S, Jolly H W
Cutis. 1976 Feb;17(2):315-20.
Variation in the severity of keratosis follicularis relative to states of homonal change was noted in eight women with the disease. Observations included frequent onset near puberty, puberty, exacerbation during menses, and improvement while patients are pregnant or on oral contraceptive agents. It is proposed that states of relative estrogen excess are associated with quiescence of this skin disorder. In support of this hypothesis, three postpubertal women with Darier desease were observed to undergo significant improvement with the use of estrogen-dominant birth control pills.
在八名患有毛囊角化病的女性中，观察到毛囊角化病严重程度相对于激素变化状态的差异。观察结果包括疾病常在青春期前后频繁发作、青春期发作、月经期间病情加重，以及患者怀孕或服用口服避孕药时病情改善。有人提出，相对雌激素过多的状态与这种皮肤疾病的静止期有关。为支持这一假说，观察到三名青春期后的达里埃病女性在使用以雌激素为主的避孕药后病情有显著改善。
