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用“米尔温试剂”进行O-和N-烷基化反应：两种内酰胺的异常行为

O- and N-alkylation with "Meerwein's reagent": the unusual behaviour of two lactams.

作者信息

Alhaique F, Cozzani R G, Riccieri F M

出版信息

Farmaco Sci. 1976 Dec;31(12):845-8.

PMID:1017478
Abstract

Usually tertiary oxonium salts are excellent O-alkylating agents of lactams; in some cases indiscriminate O- and N-alkylations have been described. In this paper the particular behaviour towards Meerwein's reagent of two isomers with a lactamic structure is pointed out: in one case the usual O-alkylation occurs, in the other N-alkylation is the only reaction that takes place.

摘要

通常，叔氧鎓盐是内酰胺出色的O-烷基化剂；在某些情况下，已报道会发生不加选择的O-和N-烷基化反应。本文指出了两种具有内酰胺结构的异构体对米尔温试剂的特殊反应：一种情况下发生常见的O-烷基化反应，而在另一种情况下，N-烷基化是唯一发生的反应。

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