Grappel S F
Dermatologica. 1976;153(3):157-62.
Complement-fixing antibodies to the heat-inactivated keratinase II of Trichophyton mentagrophytes var. granulosum were detectable in sera from approximately 40% of the Hartley strain guinea pigs previously infected with this dermatophyte. However, no precipitating antibodies to the heat-inactivated keratinase II were detectable in these sera. Guinea pigs immunized with the heat-inactivated keratinase II had both complement-fixing and precipitating antibodies to the keratinase II. Circulating antibodies in sera from both the infected and the immunized guinea pigs also reacted with the active keratinase II but did not inhibit its proteolytic activity.
在先前感染过这种皮肤癣菌的约40%的哈特利品系豚鼠血清中，可检测到针对须癣毛癣菌颗粒变种热灭活角蛋白酶II的补体结合抗体。然而，在这些血清中未检测到针对热灭活角蛋白酶II的沉淀抗体。用热灭活角蛋白酶II免疫的豚鼠产生了针对角蛋白酶II的补体结合抗体和沉淀抗体。感染和免疫豚鼠血清中的循环抗体也与活性角蛋白酶II发生反应，但不抑制其蛋白水解活性。
