Kondo T, Ichihashi H, Imaizumi M
Gan. 1976 Oct;67(5):633-9.
For the purpose of predicting the effect of carcinostatic agents on tumor-bearing host in vitro, a sensitivity test of a drug in tumor bearers was developed. This test is based on the change in the specific activity of acid phosphatase of individual tumor and liver tissue, and the difference in them was used as an indicator of effectiveness. The value was called the "effective value." The present papar is concerned with the relationship between the effective value and effectiveness of the agents in rodents and man. The results showed that the effective value became higher with increasing concentration of Mitomycin-C incubated with tumor and liver tissues. The survival time of Ehrlich carcinoma-bearing mice, which were given Mitomycin-C intraperitoneally, was longer and increase in the dose of Mitomycin-C. In ascitic or subcutaneous form of Ehrlich carcinoma, AH-130, and Yoshida sarcoma, the effective value was parallel with the survival time of or the inhibition of tumor growth in tumor-bearing animals treated with Mitomycin-C. In 25 patients with gastric carcinoma treated with Mitomycin-C, the postoperative survival time was more closely correlated with the effective value calculated by the titers of both tumor and liver than the value of tumor alone.
为了在体外预测抗癌药物对荷瘤宿主的作用，开展了一项针对荷瘤动物的药物敏感性试验。该试验基于个体肿瘤和肝脏组织酸性磷酸酶比活性的变化，并将两者的差异用作有效性指标。该数值被称为“有效值”。本文关注的是该有效值与啮齿动物及人类中药物有效性之间的关系。结果显示，随着与肿瘤和肝脏组织一起孵育的丝裂霉素C浓度增加，有效值升高。腹腔注射丝裂霉素C的荷艾氏腹水癌小鼠的存活时间更长，且丝裂霉素C剂量增加。在艾氏腹水癌或皮下癌、AH - 130以及吉田肉瘤中，有效值与接受丝裂霉素C治疗的荷瘤动物的存活时间或肿瘤生长抑制情况呈平行关系。在25例接受丝裂霉素C治疗的胃癌患者中，术后存活时间与通过肿瘤和肝脏两者滴度计算出的有效值的相关性，比仅与肿瘤值的相关性更为密切。
