睡眠调节的综合模型。

An integrated model of sleep regulation.

作者信息

Ruggiero C, Giacomini M, Schiavi G, Nobili L, Ferrillo F

机构信息

DIST, Department of Communications Computer and System Sciences, University of Genova, Italy.

出版信息

Stud Health Technol Inform. 1997;43 Pt B:581-5.

PMID:10179732

Abstract

We present a new model of sleep regulation which integrates the two process model and the limit cycle reciprocal interaction model. In the two process model the interaction of a homeostatic process (S signal) and of a circadian process determines the timing of sleep and waking. In the limit cycle model, the NREM-REM sleep cycle is generated by the reciprocal interaction of two coupled cell population. The present model integrates the two considered models introducing the trigger REM-NREM generated by the REM-ON signal and activated when REM-ON overcomes the S signal.

摘要

我们提出了一种新的睡眠调节模型，该模型整合了双过程模型和极限环相互作用模型。在双过程模型中，稳态过程（S信号）和昼夜节律过程的相互作用决定了睡眠和觉醒的时间。在极限环模型中，非快速眼动睡眠-快速眼动睡眠周期是由两个耦合细胞群体的相互作用产生的。当前模型通过引入由快速眼动开启信号产生并在快速眼动开启信号超过S信号时激活的触发快速眼动-非快速眼动，整合了上述两个模型。