Ward H A
Medical Health and Research Centre, Randwick NSW, Australia.
J Laser Appl. 1998 Oct;10(5):224-8. doi: 10.2351/1.521856.
The five years survival rate of deep-seated malignant brain tumors after surgery/radiotherapy is virtually 100% mortality. Special problems include: (1) lesions often present late; (2) position: lesions overlies vital structures, so complete surgical/radiotherapy lesion destruction can damage vital brain-stem functions; and (3) difficulty in differentiating normal brain from malignant lesions. This study aimed to use the unique properties of the laser: (a) to minimize damage during surgical removal of deep-seated brain lesions by operating via fine optic fibers; and (b) to employ the propensity of certain lasers for absorption of (nontoxic) dyes and absorption and induction of fluorescence in some brain substances, to differentiate borders of malignant and normal brain, for more complete tumor removal. A fine laser endoscopic technique was devised for removal of brain lesions, which minimized thermal damage and shock waves. A compatible endoscopic fluoroscopic laser technique was developed to differentiate brain tumor from normal brain.
深部恶性脑肿瘤经手术/放疗后的五年生存率实际上为100%的死亡率。特殊问题包括：（1）病变通常出现较晚；（2）位置：病变覆盖重要结构，因此完全通过手术/放疗破坏病变可能会损害重要的脑干功能；以及（3）难以区分正常脑组织与恶性病变。本研究旨在利用激光的独特特性：（a）通过细光纤操作，在手术切除深部脑病变时将损伤降至最低；（b）利用某些激光对（无毒）染料的吸收以及对某些脑物质的吸收和荧光诱导特性，区分恶性和正常脑的边界，以更彻底地切除肿瘤。设计了一种精细的激光内镜技术来切除脑病变，该技术将热损伤和冲击波降至最低。还开发了一种兼容的内镜荧光激光技术来区分脑肿瘤和正常脑。
