Iwasaki Y, Kato Y, Chihara K, Ohgo S, Maeda K
Neuroendocrinology. 1976;21(3):267-74. doi: 10.1159/000122532.
I.v. injection of sulpiride (S; 0.5-20 mug/100 g b.w.) caused a significant and dose-related increase in plasma prolactin (Prl) levels in urethane-anesthetized rats, with peak values occuring 10 min after the injection. L-dopa administration (2 mg/100 g b.w., i.v.) significantly blunted plasma Prl response to S(1 mug/100 g b.w., i.v.). S injection (1 mug/rat) into a lateral ventricle also raised plasma Prl significantly. Hypothalamic destruction resulted in a prominent increase of basal plasma Prl, which increased further following the injection of S. These results suggest that S stimulates Prl secretion by its possible direct action on the anterior pituitary.
静脉注射舒必利（S；0.5 - 20微克/100克体重）可使乌拉坦麻醉大鼠的血浆催乳素（Prl）水平显著且呈剂量依赖性升高，注射后10分钟出现峰值。静脉注射左旋多巴（2毫克/100克体重）可显著减弱血浆Prl对舒必利（1微克/100克体重，静脉注射）的反应。向侧脑室注射舒必利（1微克/只大鼠）也可显著提高血浆Prl水平。下丘脑损毁导致基础血浆Prl显著升高，注射舒必利后进一步升高。这些结果表明，舒必利可能通过对垂体前叶的直接作用来刺激Prl分泌。
