Jones R G, Lee L, Landon J
Department of Chemical Pathology, The Medical College of St. Bartholomew's Hospital, London.
Br J Pharmacol. 1999 Feb;126(3):581-4. doi: 10.1038/sj.bjp.0702286.
Brown snake (Pseudonaja) venom has been reported to produce 'irreversible' post synaptic neurotoxicity (Harris & Maltin, 1981; Barnett et al., 1980). A murine phrenic nerve/diaphragm preparation was used to study the neurotoxic effects of this venom and pre- and post-synaptic components were distinguished by varying the temperature and frequency of nerve stimulation. There were no myotoxic effects and the neurotoxicity proved irreversible by washing alone. The effects of a new Fab based ovine antivenom have been investigated and proved able to produce a complete, rapid (< 1 h) reversal of the neurotoxicity induced by Brown snake venom. A reversal was also possible when the antivenom addition was delayed for a further 60 min. We believe that this is the first time such a reversal has been shown.
据报道，棕蛇（伪眼镜蛇属）毒液会产生“不可逆”的突触后神经毒性（哈里斯和马尔廷，1981年；巴尼特等人，1980年）。采用小鼠膈神经/膈肌标本研究该毒液的神经毒性作用，并通过改变神经刺激的温度和频率来区分突触前和突触后成分。未观察到肌毒性作用，且仅通过冲洗证明神经毒性是不可逆的。研究了一种新型基于Fab的羊抗蛇毒血清的作用，结果表明其能够使棕蛇毒液诱导的神经毒性完全、快速（<1小时）逆转。当抗蛇毒血清添加延迟60分钟时，逆转同样可行。我们认为这是首次证明这种逆转情况。
