特定抗体片段对棕蛇（伪眼镜蛇属）毒液诱导的“不可逆”神经毒性的影响。
The effects of specific antibody fragments on the 'irreversible' neurotoxicity induced by Brown snake (Pseudonaja) venom.
作者信息
Jones R G, Lee L, Landon J
机构信息
Department of Chemical Pathology, The Medical College of St. Bartholomew's Hospital, London.
出版信息
Br J Pharmacol. 1999 Feb;126(3):581-4. doi: 10.1038/sj.bjp.0702286.
Abstract
Brown snake (Pseudonaja) venom has been reported to produce 'irreversible' post synaptic neurotoxicity (Harris & Maltin, 1981; Barnett et al., 1980). A murine phrenic nerve/diaphragm preparation was used to study the neurotoxic effects of this venom and pre- and post-synaptic components were distinguished by varying the temperature and frequency of nerve stimulation. There were no myotoxic effects and the neurotoxicity proved irreversible by washing alone. The effects of a new Fab based ovine antivenom have been investigated and proved able to produce a complete, rapid (< 1 h) reversal of the neurotoxicity induced by Brown snake venom. A reversal was also possible when the antivenom addition was delayed for a further 60 min. We believe that this is the first time such a reversal has been shown.
摘要
据报道，棕蛇（伪眼镜蛇属）毒液会产生“不可逆”的突触后神经毒性（哈里斯和马尔廷，1981年；巴尼特等人，1980年）。采用小鼠膈神经/膈肌标本研究该毒液的神经毒性作用，并通过改变神经刺激的温度和频率来区分突触前和突触后成分。未观察到肌毒性作用，且仅通过冲洗证明神经毒性是不可逆的。研究了一种新型基于Fab的羊抗蛇毒血清的作用，结果表明其能够使棕蛇毒液诱导的神经毒性完全、快速（<1小时）逆转。当抗蛇毒血清添加延迟60分钟时，逆转同样可行。我们认为这是首次证明这种逆转情况。
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本文引用的文献
1
Observations on the isolated phrenic nerve diaphragm preparation of the rat.关于大鼠膈神经膈肌分离标本的观察
Br J Pharmacol Chemother. 1946 Mar;1(1):38-61. doi: 10.1111/j.1476-5381.1946.tb00025.x.
2
The effects of taipoxin and notexin on the function and fine structure of the murine neuromuscular junction.太攀蛇毒素和诺氏蛇毒素对小鼠神经肌肉接头功能及精细结构的影响。
Neuroscience. 1976 Jun;1(3):175-80. doi: 10.1016/0306-4522(76)90074-9.
3
Picosecond to hour time scale dynamics of a "three finger" toxin: correlation with its toxic and antigenic properties.“三指”毒素的皮秒至小时时间尺度动力学：与其毒性和抗原特性的相关性
Biochemistry. 1997 Dec 23;36(51):16097-108. doi: 10.1021/bi971293k.
4
Identification of the site at which phospholipase A2 neurotoxins localize to produce their neuromuscular blocking effects.鉴定磷脂酶A2神经毒素产生神经肌肉阻滞作用的定位位点。
Toxicon. 1993 Jan;31(1):13-26. doi: 10.1016/0041-0101(93)90352-j.
5
A new antivenom to treat eastern coral snake (Micrurus fulvius fulvius) envenoming.一种用于治疗东部珊瑚蛇（佛罗里达珊瑚蛇）咬伤的新型抗蛇毒血清。
Toxicon. 1994 Feb;32(2):185-90. doi: 10.1016/0041-0101(94)90107-4.
6
Mapping of two "neutralizing" epitopes of a snake curaremimetic toxin by proton nuclear magnetic resonance spectroscopy.利用质子核磁共振光谱法对一种蛇毒类箭毒毒素的两个“中和”表位进行图谱分析。
Biochemistry. 1993 Jul 13;32(27):6884-91. doi: 10.1021/bi00078a011.
7
A neurotoxin of novel structural type from the venom of the Australian common brown snake.一种源自澳大利亚普通棕蛇毒液的新型结构类型的神经毒素。
Naturwissenschaften. 1980 Aug;67(8):405-6. doi: 10.1007/BF00405486.
8
A study of the major Australian snake venoms in the monkey (Macaca fascicularis). II. Myolytic and haematological effects of venoms.澳大利亚主要蛇毒对猕猴（食蟹猴）作用的研究。II. 蛇毒的溶肌和血液学效应
Pathology. 1981 Oct;13(4):705-15. doi: 10.3109/00313028109086644.
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Neurotoxin-specific immunoglobulins accelerate dissociation of the neurotoxin-acetylcholine receptor complex.神经毒素特异性免疫球蛋白可加速神经毒素 - 乙酰胆碱受体复合物的解离。
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