Sherman M A, Kennedy J P, Ely D L, Smith D
Department of Polymer Science, The University of Akron, OH 44325, USA.
J Biomater Sci Polym Ed. 1999;10(3):259-69. doi: 10.1163/156856299x00333.
The tissue biocompatibility of a series of novel rubbery polyisobutylene (PIB)/polydimethylsiloxane (PDMS) bicomponent networks was investigated by in vivo implantation into rats. Bicomponent networks of varying composition (PIB wt%/PDMS wt% = 70/30, 50/50, 35/65) as well as a standard polyethylene control were implanted intraperitoneally. After eight weeks the implants and surrounding tissue were removed for histological evaluation. In all scoring categories (i.e. collagen thickness, fibrous tissue orientation, collagen deposition in muscle tissue, lymphocyte infiltration, angiogenesis) the PIB/PDMS bicomponent network implants elicited either less or similar tissue and cellular response than polyethylene. To determine which implant elicited the least tissue and cellular response overall, a weighted score including collagen thickness, lymphocyte infiltration, and angiogenesis was calculated for each implant. According to these preliminary investigations, PIB/PDMS bicomponent networks are suitable for implant applications.
通过将一系列新型橡胶状聚异丁烯（PIB）/聚二甲基硅氧烷（PDMS）双组分网络体内植入大鼠来研究其组织生物相容性。将不同组成的双组分网络（PIB重量百分比/PDMS重量百分比 = 70/30、50/50、35/65）以及标准聚乙烯对照物腹腔内植入。八周后，取出植入物和周围组织进行组织学评估。在所有评分类别（即胶原厚度、纤维组织取向、肌肉组织中的胶原沉积、淋巴细胞浸润、血管生成）中，PIB/PDMS双组分网络植入物引发的组织和细胞反应比聚乙烯少或相似。为了确定哪种植入物总体上引发的组织和细胞反应最少，为每个植入物计算了包括胶原厚度、淋巴细胞浸润和血管生成的加权分数。根据这些初步研究，PIB/PDMS双组分网络适用于植入应用。
