Aguas A P, Esaguy N, Grande N R, Castro A P, Castelo Branco N A
Abel Salazar Institute for Biomedical Sciences, University of Porto, Portugal.
Aviat Space Environ Med. 1999 Mar;70(3 Pt 2):A132-6.
We investigated the effect of low frequency noise on the natural history of autoimmune diseases using hybrid New Zealand Black (NZB) and White (NZW) male mice that are prone to spontaneously develop systemic lupus erythematosus after 6 mo of age.
We exposed 3-mo-old mice to periods of low frequency noise (> or = 90 dB SPL, < or = 500 Hz) for a total of 216 h; the animals were studied up to 12 mo of age and data were compared with results obtained with age-matched controls.
We found that noise exposure caused an earlier expression of proteinuria, a change that was associated with acceleration of kidney lesions and increased mortality. At 8 mo of age, after 3 mo of chronic exposure to noise, the exposed mice presented significantly higher numbers of splenic IgM+ lymphocytes and CD8+ T cells than the age-matched controls.
Exposure of lupus-prone mice to low frequency noise accelerates the expression of the autoimmune disease and it affects the immune system by raising the number of splenic IgM+ B lymphocytes and CD8+ T cells.
我们使用杂交的新西兰黑（NZB）和白（NZW）雄性小鼠研究了低频噪声对自身免疫性疾病自然病程的影响，这些小鼠在6月龄后容易自发发展为系统性红斑狼疮。
我们将3月龄小鼠暴露于低频噪声（≥90 dB SPL，≤500 Hz）中，总时长为216小时；对这些动物进行长达12月龄的研究，并将数据与年龄匹配的对照组结果进行比较。
我们发现噪声暴露导致蛋白尿更早出现，这种变化与肾脏病变加速和死亡率增加有关。在8月龄时，经过3个月的慢性噪声暴露后，暴露组小鼠脾脏中IgM+淋巴细胞和CD8+T细胞的数量明显高于年龄匹配的对照组。
易患狼疮的小鼠暴露于低频噪声会加速自身免疫性疾病的发展，并通过增加脾脏中IgM+B淋巴细胞和CD8+T细胞的数量来影响免疫系统。
