Udoh F V
Department of Pharmacology, College of Medical Sciences, University of Calabar, Nigeria.
Phytother Res. 1999 Feb;13(1):55-8. doi: 10.1002/(SICI)1099-1573(199902)13:1<55::AID-PTR401>3.0.CO;2-3.
The leaf and seed of Piper guineense were separately extracted and the effects of repeated treatments on rat uterine contractions and their chemical composition were investigated. Repeated treatments with the extracts enhanced spontaneous uterine muscle contractions in a dose related pattern for up to 14 days which was followed by a marked decrease in uterine response in those treated for 30 days. Similarly, the pretreatment with the extracts maximally enhanced oxytocin induced uterine contraction in those rats treated for 3 days, this was followed by a gradual reversal of the effect when treatment was repeated for up to 14 days. This enhanced uterine contraction was inhibited following treatment for 30 days. In a further study, treatment with the extracts induced a significant increase in the uterine weight similar to that seen with oestradiol. It is therefore concluded that the leaf and seed extracts of Piper guineense possess oestrogenic and oxytocic properties which might justify their usage in Nigerian traditional medicine.
分别提取了几内亚胡椒的叶子和种子，并研究了重复处理对大鼠子宫收缩及其化学成分的影响。提取物的重复处理以剂量相关模式增强自发性子宫肌肉收缩，持续长达14天，之后在接受30天处理的大鼠中子宫反应显著降低。同样，提取物预处理在接受3天处理的大鼠中最大程度地增强了催产素诱导的子宫收缩，当重复处理长达14天时，这种作用随后逐渐逆转。在接受30天处理后，这种增强的子宫收缩受到抑制。在进一步的研究中，提取物处理导致子宫重量显著增加，类似于雌二醇的作用。因此得出结论，几内亚胡椒的叶子和种子提取物具有雌激素和催产素特性，这可能证明它们在尼日利亚传统医学中的应用是合理的。
