Bader R S, Telang G H, Vonderheid E C
Department of Dermatology, Allegheny University Hospitals, Philadelphia, Pennsylvania 19107, USA.
Cutis. 1999 Mar;63(3):145-8.
Multinucleate-cell angiohistiocytoma (MCAH) is a benign vascular proliferation of unknown etiology. Clinically, MCAH presents as grouped, erythematous, or violaceous papules on the extremities in older women. These lesions often resemble Kaposi's sarcoma. Histologic examination reveals characteristic bizarre-shaped, multinucleate giant cells, some of which contain three to six nuclei arranged in a ring-like or overlapping pattern, which stain positively for Factor XIIIa. In addition, there is a proliferation of dermal capillaries and venules with a mild lymphohistiocytic infiltrate. To our knowledge, this is the first reported case of MCAH occurring in a patient with mycosis fungoides.
多核细胞血管组织细胞瘤（MCAH）是一种病因不明的良性血管增殖性疾病。临床上，MCAH表现为老年女性四肢出现成群的红斑或紫红色丘疹。这些损害常类似卡波西肉瘤。组织学检查显示特征性的怪异形状的多核巨细胞，其中一些含有三到六个呈环状或重叠排列的核，这些核对因子ⅩⅢa呈阳性染色。此外，真皮毛细血管和小静脉增生，伴有轻度淋巴细胞和组织细胞浸润。据我们所知，这是首例报告的蕈样肉芽肿患者发生MCAH的病例。
