Casino C, Lilli D, Rivanera D, Sabrina C, Rossi M, Casciaro G, Alfani D, Mancini C
I Chair, School of Medicine, La Sapienza, University of Rome, Italy.
New Microbiol. 1999 Jan;22(1):11-8.
In this study, we evaluated the correlation between alanine aminotrasferase levels and hepatitis C virus genotypes in liver transplant patients. We studied 18 patients who had undergone orthotopic liver transplantation because of end-stage cirrhosis (n = 9) or hepatocellular carcinoma (n = 9) hepatitis C virus related. Serum HCV-RNA testing was performed monthly on all the 18 series of serum samples from the first week after liver transplant until the end of the follow up, this period ranging from 1 to 39 months. After liver transplantation, serum HCV-RNA was detected in 14 patients (78%). Of the 8 patients infected with subtype 1b. 1 remained asymptomatic, 2 developed acute liver failure and 5 developed chronic hepatitis. In patients infected with types 1a (Choo et al., 1989), 2a (Choo et al., 1989), with a mixed infection 1b/3 (Kuo et al., 1989) or with an undetermined genotype, significant laboratory abnormalities were not observed. Recurrence of hepatitis C virus infection after liver transplantation is common, and recurrent hepatitis occurs in 50% of cases. Genotype 1b appears to be associated with a higher rate of recurrent hepatitis, compared to other genotypes.
在本研究中，我们评估了肝移植患者丙氨酸转氨酶水平与丙型肝炎病毒基因型之间的相关性。我们研究了18例因终末期肝硬化（n = 9）或丙型肝炎病毒相关的肝细胞癌（n = 9）而接受原位肝移植的患者。从肝移植后第一周直至随访结束，每月对这18例患者的系列血清样本进行血清HCV-RNA检测，随访期为1至39个月。肝移植后，14例患者（78%）检测到血清HCV-RNA。在8例感染1b亚型的患者中，1例无症状，2例发生急性肝衰竭，5例发生慢性肝炎。在感染1a型（Choo等人，1989年）、2a型（Choo等人，1989年）、混合感染1b/3型（Kuo等人，1989年）或基因型未确定的患者中，未观察到明显的实验室异常。肝移植后丙型肝炎病毒感染复发很常见，50%的病例会出现复发性肝炎。与其他基因型相比，1b型似乎与更高的复发性肝炎发生率相关。
