Tantengco M V, Humes R A, Clapp S K, Lobdell K W, Walters H L, Hakimi M, Epstein M L
Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit 48201, USA.
Am J Cardiol. 1999 Mar 15;83(6):915-20. doi: 10.1016/s0002-9149(98)01062-5.
This study evaluated changes in neoaortic root geometry in patients who underwent the Ross procedure. Serial postoperative echocardiographic measurements of the neoaortic root indexed to the square root of body surface area (centimeters divided by meters) were obtained from 30 patients (age range 3.1 to 31.4 years) and compared with paired preoperative and immediate postoperative values. Normal aortic root diameter Z scores were derived from root dimensions obtained from 217 healthy controls. Compared with preoperative values, an immediate stretch of the neoaortic versus pulmonary root (annulus and sinuses of valsalva) was observed at a mean follow-up period of 1 week. Additional aortic annular dilation from baseline prehospital discharge values was observed at 2 to 12 months (baseline vs follow-up annulus Z score: 1.4 vs 2.6, p <0.01, n = 16) and at 16 to 33 months follow-up (0.8 vs 2.0, p <0.05, n = 12). In a similar fashion, there was additional enlargement of the aortic sinus from its stretched state at hospital discharge at 2 to 12 months (baseline vs follow-up sinus Z score: 2.0 vs 3.3, p <0.01, n = 17) and at 16 to 33 months (1.7 vs 3.0, p <0.01, n = 13). There were no differences in root size between 2 to 12 and 16 to 33 months after surgery. There was a decrease in left ventricular size with no alteration in blood pressure or degree of aortic valve regurgitation. Thus, aortic root dilation occurs up to the first year after the Ross procedure but does not appear to progress beyond this time.
本研究评估了接受Ross手术患者新主动脉根部几何形态的变化。从30例患者(年龄范围3.1至31.4岁)获取术后系列经胸超声心动图测量结果,将新主动脉根部测量值除以体表面积的平方根(厘米除以米)进行指数化,并与术前和术后即刻的配对值进行比较。正常主动脉根部直径Z值来自217名健康对照者的根部尺寸。与术前值相比,在平均随访1周时观察到新主动脉根部相对于肺动脉根部(瓣环和主动脉窦)即刻伸展。在出院后2至12个月(基线与随访时瓣环Z值:1.4对2.6,p<0.01,n = 16)以及随访16至33个月时(0.8对2.0,p<0.05,n = 12),观察到主动脉瓣环较出院前基线值有额外扩张。同样,在出院后2至12个月(基线与随访时窦部Z值:2.0对3.3,p<0.01,n = 17)以及16至33个月时(1.7对3.0,p<0.01,n = 13),主动脉窦从出院时的伸展状态有额外增大。术后2至12个月与16至33个月之间根部大小无差异。左心室大小减小,血压或主动脉瓣反流程度无改变。因此,Ross手术后直至第一年主动脉根部都会扩张,但此后似乎不再进展。