TRANCE-RANK, a new signal pathway involved in lymphocyte development and T cell activation.
作者信息
Green E A, Flavell R A
机构信息
Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
出版信息
J Exp Med. 1999 Apr 5;189(7):1017-20. doi: 10.1084/jem.189.7.1017.
Abstract
摘要
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TRANCE-RANK, a new signal pathway involved in lymphocyte development and T cell activation.TRANCE-RANK，一种参与淋巴细胞发育和T细胞活化的新信号通路。
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TRANCE together with IL-7 induces pre-B cells to proliferate.肿瘤坏死因子相关凋亡诱导配体（TRANCE）与白细胞介素-7（IL-7）共同诱导前B细胞增殖。
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RANK is essential for osteoclast and lymph node development.RANK对破骨细胞和淋巴结发育至关重要。
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TRANCE-RANK costimulation is required for IL-12 production and the initiation of a Th1-type response to Leishmania major infection in CD40L-deficient mice.TRANCE-RANK共刺激对于IL-12的产生以及CD40L缺陷小鼠针对利什曼原虫主要感染引发Th1型反应是必需的。
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TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells.TRANCE是肿瘤坏死因子受体家族的一种新型配体，可激活T细胞中的c-Jun氨基末端激酶。
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CD40-independent pathways of T cell help for priming of CD8(+) cytotoxic T lymphocytes.T细胞辅助启动CD8(+) 细胞毒性T淋巴细胞的不依赖CD40途径。
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本文引用的文献
1
TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation.TRANCE，一种对不依赖CD40配体的T辅助细胞激活至关重要的肿瘤坏死因子家族成员。
J Exp Med. 1999 Apr 5;189(7):1025-31. doi: 10.1084/jem.189.7.1025.
2
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.骨保护素配体是破骨细胞生成、淋巴细胞发育和淋巴结器官发生的关键调节因子。
Nature. 1999 Jan 28;397(6717):315-23. doi: 10.1038/16852.
3
CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection.CD40配体介导的相互作用参与记忆性CD8(+)细胞毒性T淋巴细胞（CTL）的产生，但在病毒感染后维持CTL记忆方面并非必需。
J Virol. 1998 Sep;72(9):7440-9. doi: 10.1128/JVI.72.9.7440-7449.1998.
4
CD40 and CD154 in cell-mediated immunity.细胞介导免疫中的CD40和CD154
Annu Rev Immunol. 1998;16:111-35. doi: 10.1146/annurev.immunol.16.1.111.
5
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.骨保护素配体是一种调节破骨细胞分化和激活的细胞因子。
Cell. 1998 Apr 17;93(2):165-76. doi: 10.1016/s0092-8674(00)81569-x.
6
Dendritic cells and the control of immunity.树突状细胞与免疫调控
Nature. 1998 Mar 19;392(6673):245-52. doi: 10.1038/32588.
7
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.破骨细胞分化因子是骨保护素/破骨细胞生成抑制因子的配体，与肿瘤坏死因子相关激活诱导因子/核因子κB受体活化因子配体相同。
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3597-602. doi: 10.1073/pnas.95.7.3597.
8
TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor.TRANCE（肿瘤坏死因子相关激活诱导细胞因子）是肿瘤坏死因子（TNF）家族的一个新成员，主要在T细胞中表达，是一种树突状细胞特异性存活因子。
J Exp Med. 1997 Dec 15;186(12):2075-80. doi: 10.1084/jem.186.12.2075.
9
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.肿瘤坏死因子受体及其配体的同源物可增强T细胞生长和树突状细胞功能。
Nature. 1997 Nov 13;390(6656):175-9. doi: 10.1038/36593.
10
Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice.淋巴毒素β缺陷小鼠揭示了淋巴毒素α和β在淋巴器官发生中的不同作用。
Immunity. 1997 Apr;6(4):491-500. doi: 10.1016/s1074-7613(00)80292-7.
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