在斐济，五年每年单次服用乙胺嗪治疗淋巴丝虫病的疗效。
Efficacy of five annual single doses of diethylcarbamazine for treatment of lymphatic filariasis in Fiji.
作者信息
Mataika J U, Kimura E, Koroivueta J, Shimada M
机构信息
Wellcome Virus Laboratory, Tamavua Hospital, Suva, Fiji.
出版信息
Bull World Health Organ. 1998;76(6):575-9.
Abstract
Annual single-dose treatments with diethylcarbamazine citrate (DEC) at a dose of 6 mg/kg have been reported effective in reducing microfilariae (mf) rate and density and applicable to large-scale filariasis control campaigns. However, the efficacy of such treatments has not been studied quantitatively in relation to different pretreatment levels of endemicity. This study of 32 villages in Fiji revealed that five treatments repeated annually steadily reduced village mf rate, and that the degree of reduction was not influenced by pretreatment levels of mf density or rate. This indicates that an annual dosage scheme is applicable to high-endemicity areas. The results also suggest that such treatment affected juvenile forms of Wuchereria bancrofti and may prevent them from reproducing.
摘要
据报道，每年单剂量服用6毫克/千克枸橼酸乙胺嗪（DEC）可有效降低微丝蚴（mf）率和密度，并适用于大规模丝虫病防治运动。然而，尚未针对不同的流行程度预处理水平对这类治疗的疗效进行定量研究。对斐济32个村庄的这项研究表明，每年重复进行五次治疗可稳步降低村庄的微丝蚴率，且降低程度不受微丝蚴密度或率的预处理水平影响。这表明年度给药方案适用于高流行地区。结果还表明，这种治疗会影响班氏吴策线虫的幼虫形态，并可能阻止它们繁殖。
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