Fagard R, Amery A, Ljnen P, Reybrouck T, Billiet L
Prog Biochem Pharmacol. 1976;12:242-9.
Sar1-Ala8-angiotensin II was infused intravenously (10 mug/kg/min) in 14 patients with renovascular hypertension, including 11 with renal artery stenosis. Brachial artery pressure and heart rate remained unchanged in six patients who were on a daily sodium intake of 130 mEq. In 12 tests performed after sodium depletion, the decrease in mean arterial pressure ranged from 13 to 76 mm Hg and showed a significant correlation with the plasma renin concentration prevailing immediately before the infusion of the drug (r = 0.81; p less than 0.001). The hypotensive response was due to a drop in total peripheral resistance. Heart rate and cardiac output showed slight increases 10 min after the start of saralasin infusion.
对14例肾血管性高血压患者（其中11例有肾动脉狭窄）静脉输注Sar1 - Ala8 - 血管紧张素II（10微克/千克/分钟）。14例患者中，6例每日钠摄入量为130毫当量，其肱动脉血压和心率保持不变。在12次钠耗竭后进行的测试中，平均动脉压下降幅度为13至76毫米汞柱，且与输注药物前即刻的血浆肾素浓度显著相关（r = 0.81；p < 0.001）。降压反应是由于总外周阻力下降所致。在开始输注沙拉新10分钟后，心率和心输出量略有增加。
