Synthesis and pharmacological activities of novel 3-(isoxazol-3-yl)-quinazolin-4(3H)-one derivatives.

作者信息

Daidone G, Raffa D, Maggio B, Plescia F, Cutuli V M, Mangano N G, Caruso A

机构信息

Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Palermo, Italy.

出版信息

Arch Pharm (Weinheim). 1999 Feb;332(2):50-4. doi: 10.1002/(sici)1521-4184(19993)332:2<50::aid-ardp50>3.0.co;2-s.

Several new 3-(isoxazol-3-yl)-quinazolin-4(3H)-one derivatives were synthesized and tested for their analgesic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effect. A few compounds were as active as phenylbutazone in the writhing and acetic acid peritonitis tests. They had a very low ulcerogenic effect.