异恶唑衍生物作为植物中新型一氧化氮诱导剂
Isoxazole derivatives as new nitric oxide elicitors in plants.
作者信息
Oancea Anca, Georgescu Emilian, Georgescu Florentina, Nicolescu Alina, Oprita Elena Iulia, Tudora Catalina, Vladulescu Lucian, Vladulescu Marius-Constantin, Oancea Florin, Deleanu Calin
机构信息
National Institute of Research and Development for Biological Sciences, Spl. Independentei 296, RO-060031 Bucharest, Romania.
Research Center Oltchim, Str. Uzinei 1, RO-240050, Ramnicu Valcea, Romania.
出版信息
Beilstein J Org Chem. 2017 Apr 6;13:659-664. doi: 10.3762/bjoc.13.65. eCollection 2017.
Several 3,5-disubstituted isoxazoles were obtained in good yields by regiospecific 1,3-dipolar cycloaddition reactions between aromatic nitrile oxides, generated in situ from the corresponding hydroxyimidoyl chlorides, with non-symmetrical activated alkynes in the presence of catalytic amounts of copper(I) iodide. Effects of 3,5-disubstituted isoxazoles on nitric oxide and reactive oxygen species generation in tissues was studied using specific diaminofluoresceine dyes as fluorescence indicators.
通过在催化量的碘化亚铜存在下，由相应的羟基亚氨酰氯原位生成的芳族腈氧化物与不对称活化炔烃进行区域特异性1,3 - 偶极环加成反应，以良好的产率得到了几种3,5 - 二取代异恶唑。使用特定的二氨基荧光素染料作为荧光指示剂，研究了3,5 - 二取代异恶唑对组织中一氧化氮和活性氧生成的影响。
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